Van Dijk skilled previous within the week however misses out with a good hamstring.
It manner Dejan Lovren is available in to interchange the Dutchman. Elsewhere, Mohamed Salah and Georginio Wijnaldum additionally get started with Adam Lallana and James Milner losing to the bench.
Loris Karius is most well-liked over Simon Mignolet in purpose.
For City, Kyle Walker, Nicolas Otamendi and Fabian Delph go back to the defence following the midweek win over Bristol City 2-1 within the EFL Cup.
Fernandinho takes where of Yaya Toure, whilst Sergio Aguero additionally begins.
Liverpool: Karius, Gomez, Lovren, Matip, Robertson, Wijnaldum, Can, Oxlade-Chamberlain, Salah, Mane, Firmino
Subs: Mignolet, Milner, Klavan, Lallana, Ings, Solanke, Alexander-Arnold
Man City: Ederson, Walker, Otamendi, Stokes, Delph, Fernandinho, Gundogan, Sterling, De Bruyne, Sane, Aguero
Subs: Bravo, Danilo, Mangala, D.Silva, B.Silva, Zinchenko, Diaz