Jones ignored Manchester United’s opening Group A win over Basel previous this month because of suspension.
The England defender has served his European ban however Mourinho admits he’s going to now not function for his or her commute to Moscow.
United posted on Twitter: “Jose Mourinho tells #MUTV Phil Jones will also miss Wednesday’s #UCL meeting with CSKA Moscow.”
Jones has been key to United’s good fortune within the Premier League this season, beginning all six video games along Eric Bailly.
Mourinho must make a decision whether or not to stay religion in Chris Smalling and Victor Lindelof from their win over Basel or herald Bailly.
The United boss additionally faces a predicament in midfield, with Marouane Fellaini and Michael Carrick becoming a member of Paul Pogba within the remedy room.
He stated: “We don’t have Fellaini, Pogba or Carrick, so all 3 midfield avid gamers we lose for this fit, so the answers aren’t many.
“But we attempt now not to concentrate on particular person battles at the pitch, we’re going to have a group with high quality and stability to check out to win the fit, which is the target.”
On Fellaini, Mourinho added: “I do not expect him to be out for long. He was lucky, it could have been a much worse situation.”