Left-back Mendy limped off all the way through Saturday’s Five-Zero destruction of Crystal Palace, which made Guardiola’s crew the outright Premier League leaders.
Fabian Delph and Danilo are each in competition to begin if the France global fails to get well in time.
Midfielder Ilkay Gundogan and centre-back Vincent Kompany will indubitably pass over out, in spite of being again in coaching after fresh injury issues.
Gundogan sprained his left knee all the way through closing Wednesday’s 2-1 Carabao Cup third-round win at West Brom, whilst Kompany suffered a calf injury taking part in for Belgium in opposition to Gibraltar in a World Cup qualifier on the finish of August.
Guardiola mentioned of Mendy: “We are going to present him a test to peer if he is in a position to play.
“Ilkay educated the previous day and so did Vincent, however nor is in a position for Tuesday.”
Manchester City have received seven out of 8 video games in all competitions thus far, however Guardiola has warned in opposition to complacency.
He mentioned: “It is the 7th time I’ve performed in opposition to Shakhtar in my profession, as soon as within the Super Cup and 3 within the Champions League, and each and every time before I’ve the similar feeling.
“The first time we are facing within the crew degree, my crew went to peer them and got here again announcing ‘wow’. My crew had been actually inspired. Fernandinho performed and Douglas Costa they usually had a large number of Brazilians.
“In Barcelona at all times it was once the similar. ‘Shakhtar, Ukraine, who cares? Which players play? Nobody knows them.’
“I will be able to guarantee you they had been some of the easiest groups when it comes to taking part in soccer. They had 5 or 6 Brazilians. Always was once so tricky for me.”