Mourinho rested quite a lot of first-team avid gamers towards Burton within the Carabao Cup on Wednesday.
But the likes of Romelu Lukaku, Nemanja Matic and David De Gea have all returned for lately’s sport at St Mary’s.
Southampton: Forster, Cedric, Hoedt, Yoshida, Bertrand, Lemina, Romeu, Tadic, Davis, Redmond, Long
Subs: McCarthy, Van Dijk, Pied, Ward-Prowse, Hojberg, Gabbiadini, Austin
Manchester United: De Gea, Valencia, Bailly, Jones, Young, Matic, Fellaini, Mata, Mkhitaryan, Rashford, Lukaku
Subs: Romero, Blind, Smalling, Carrick, Herrera, Lingard, Martial